Article
Single-cell sequencing maps gene expression to mutational phylogenies in PDGF- and EGF-driven gliomas.
Molecular systems biology - 25 Nov 2016
Müller Sören, Liu Siyuan John, Di Lullo Elizabeth, Malatesta Martina, Pollen Alex A, Nowakowski Tomasz J, Kohanbash Gary, Aghi Manish, Kriegstein Arnold R, Lim Daniel A, Diaz Aaron
Abstract excerpt
Glioblastoma multiforme (GBM) is the most common and aggressive type of primary brain tumor. Epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) receptors are frequently amplified and/or possess gain-of-function mutations in GBM However, clinical trials of tyrosine-kinase inhibitors have shown disappointing efficacy, in part due to intra-tumor heterogeneity. To assess the effect of clonal...
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