Article
Emerging concepts in glioma biology: implications for clinical protocols and rational treatment strategies.
Neurosurgical focus - 15 Oct 2005
Wiesner Stephen M, Freese Andrew, Ohlfest John R
Abstract excerpt
Glioblastoma multiforme (GBM), the most common primary central nervous system neoplasm, is a complex, heterogeneous disease. The recent identification of stem cells in murine tumor xenografts that were capable of recapitulating the tumor phenotype adds a new dimension of complexity to the already challenging treatment of patients with GBMs. Although specific cellular and genetic changes are commonly associated...
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