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Article

EGFR heterogeneity and implications for therapeutic intervention in glioblastoma.

Neuro-oncology - 18 May 2018

Eskilsson Eskil, Røsland Gro V, Solecki Gergely, Wang Qianghu, Harter Patrick N, Graziani Grazia, Verhaak Roel G W, Winkler Frank, Bjerkvig Rolf, Miletic Hrvoje

Abstract excerpt

Patients with glioblastoma (GBM) have a universally poor prognosis and are in urgent need of effective treatment strategies. Recent advances in sequencing techniques unraveled the complete genomic landscape of GBMs and revealed profound heterogeneity of individual tumors even at the single cell level. Genomic profiling has detected epidermal growth factor receptor (EGFR) gene alterations in more than half of...

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Source

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Identifiers

PMID: 29040782
DOI: 10.1093/neuonc/nox191
PMCID: PMC5961011

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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