Article
Targeted sequencing of SMO and AKT1 in anterior skull base meningiomas.
Journal of neurosurgery - 1 Aug 2017
Strickland Matthew R, Gill Corey M, Nayyar Naema, D'Andrea Megan R, Thiede Christian, Juratli Tareq A, Schackert Gabriele, Borger Darrell R, Santagata Sandro, Frosch Matthew P, Cahill Daniel P, Brastianos Priscilla K, Barker Fred G
Abstract excerpt
OBJECTIVE Meningiomas located in the skull base are surgically challenging. Recent genomic research has identified oncogenic SMO and AKT1 mutations in a small subset of meningiomas. METHODS The authors performed targeted sequencing in a large cohort of patients with anterior skull base meningiomas (n = 62) to better define the frequency of SMO and AKT1 mutations in these tumors. RESULTS The authors found SMO...
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