Article
Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations.
Nature genetics - 1 Mar 2013
Brastianos Priscilla K, Horowitz Peleg M, Santagata Sandro, Jones Robert T, McKenna Aaron, Getz Gad, Ligon Keith L, Palescandolo Emanuele, Van Hummelen Paul, Ducar Matthew D, Raza Alina, Sunkavalli Ashwini, Macconaill Laura E, Stemmer-Rachamimov Anat O, Louis David N, Hahn William C, Dunn Ian F, Beroukhim Rameen
Abstract excerpt
Meningiomas are the most common primary nervous system tumor. The tumor suppressor NF2 is disrupted in approximately half of all meningiomas, but the complete spectrum of genetic changes remains undefined. We performed whole-genome or whole-exome sequencing on 17 meningiomas and focused sequencing on an additional 48 tumors to identify and validate somatic genetic alterations. Most meningiomas had simple genomes,...
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