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Article

Genetic landscape of meningioma.

Brain tumor pathology - 1 Oct 2016

Yuzawa Sayaka, Nishihara Hiroshi, Tanaka Shinya

Abstract excerpt

Meningioma is the most common intracranial tumor, arising from arachnoid cells of the meninges. Monosomy 22 and inactivating mutations of NF2 are well-known genetic alterations of meningiomas. More recently, mutations in TRAF7, AKT1, KLF4, SMO, and PIK3CA were identified by next-generation sequencing. We here reviewed 553 meningiomas for the mutational patterns of the six genes. NF2 aberration was observed in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27624470
DOI: 10.1007/s10014-016-0271-7

Genes

TRAF7
AKT1
KLF4
SMO

Provenance

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