Article
Genetic characterization and mutational profiling of foramen magnum meningiomas: a multi-institutional study.
Journal of neurosurgery - 1 Jul 2024
Hua Lingyang, Alkhatib Majd, Fujio Shingo, Alhasan Boshr, Herold Sylvia, Zeugner Silke, Zolal Amir, Hijazi Mido M, Clark Victoria E, Wakimoto Hiroaki, Shankar Ganesh M, Brastianos Priscilla K, Barker Frederick G, Cahill Daniel P, Ren Leihao, Eyüpoglu Ilker Y, Gong Ye, Schackert Gabriele, Juratli Tareq A
Abstract excerpt
OBJECTIVE: Foramen magnum (FM) meningiomas pose significant surgical challenges and have high morbidity and mortality rates. This study aimed to investigate the distribution of clinically actionable mutations in FM meningiomas and identify clinical characteristics associated with specific mutational profiles. METHODS: The authors conducted targeted next-generation sequencing of 62 FM meningiomas from three...
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