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Article

Frequent AKT1E17K mutations in skull base meningiomas are associated with mTOR and ERK1/2 activation and reduced time to tumor recurrence.

Neuro-oncology - 1 Aug 2017

Yesilöz Ümmügülsüm, Kirches Elmar, Hartmann Christian, Scholz Johannes, Kropf Siegfried, Sahm Felix, Nakamura Makoto, Mawrin Christian

Abstract excerpt

BACKGROUND: Skull base meningiomas are considered to be difficult for surgical treatment. We wondered whether genetic alterations recently identified in benign non-NF2-mutated World Health Organization (WHO) grade I meningiomas are related to clinical features of skull base meningiomas and whether druggable signaling pathways are activated. METHODS: We analyzed 93 skull base meningiomas (82 WHO grade I, 11 WHO...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28482067
DOI: 10.1093/neuonc/nox018
PMCID: PMC5570238

Genes

KLF4
SMO
TERT
AKT1
TRAF7

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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