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Article

SMO mutation status defines a distinct and frequent molecular subgroup in olfactory groove meningiomas.

Neuro-oncology - 1 Mar 2017

Boetto Julien, Bielle Franck, Sanson Marc, Peyre Matthieu, Kalamarides Michel

Abstract excerpt

Background: Meningiomas are the most common primary intracranial tumors in adults. Identification of SMO and AKT1 mutations in meningiomas has raised the hope for targeted therapies. It would be useful to know the precise frequency of these mutations in anatomical subgroups and clarify their prognostic value. Methods: We used the Sanger sequencing technique to characterize 79 samples of olfactory groove...

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Source

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Identifiers

PMID: 28082415
DOI: 10.1093/neuonc/now276
PMCID: PMC5464306

Genes

SMO
AKT1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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