Article
Oncogenic PI3K mutations are as common as AKT1 and SMO mutations in meningioma.
Neuro-oncology - 1 May 2016
Abedalthagafi Malak, Bi Wenya Linda, Aizer Ayal A, Merrill Parker H, Brewster Ryan, Agarwalla Pankaj K, Listewnik Marc L, Dias-Santagata Dora, Thorner Aaron R, Van Hummelen Paul, Brastianos Priscilla K, Reardon David A, Wen Patrick Y, Al-Mefty Ossama, Ramkissoon Shakti H, Folkerth Rebecca D, Ligon Keith L, Ligon Azra H, Alexander Brian M, Dunn Ian F, Beroukhim Rameen, Santagata Sandro
Abstract excerpt
BACKGROUND: Meningiomas are the most common primary intracranial tumor in adults. Identification of SMO and AKT1 mutations in meningiomas has raised the possibility of targeted therapies for some patients. The frequency of such mutations in clinical cohorts and the presence of other actionable mutations in meningiomas are important to define. METHODS: We used high-resolution array-comparative genomic...
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