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Article

GAB1 overexpression identifies hedgehog-activated anterior skull base meningiomas.

Neuropathology and applied neurobiology - 1 Oct 2021

Boetto Julien, Lerond Julie, Peyre Matthieu, Tran Suzanne, Marijon Pauline, Kalamarides Michel, Bielle Franck

Abstract excerpt

AIMS: Mutations activating the hedgehog (Hh) signalling pathway have been described in anterior skull base meningiomas, raising hope for the use of targeted therapies. However, identification of Hh-activated tumours is hampered by the lack of a reliable immunohistochemical marker. We report the evaluation of GAB1, an immunohistochemical marker used to detect Hh pathway activation in medulloblastoma, as a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34056767
DOI: 10.1111/nan.12740

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