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Article

Mitochondrial reactive oxygen species suppress humoral immune response through reduction of CD19 expression in B cells in mice.

European journal of immunology - 1 Feb 2017

Ogura Masato, Inoue Takeshi, Yamaki Junko, Homma Miwako K, Kurosaki Tomohiro, Homma Yoshimi

Abstract excerpt

Reactive oxygen species (ROS) are implicated in the modulation of diverse processes including immune responses. To evaluate the effects of metabolic ROS produced by mitochondria on B-cell function and development, we created transgenic (Tg) mice expressing a phosphorylation-defective mutant of succinate dehydrogenase A in B cells (bSDHAY215F ). Splenic B cells in male, but not female, bSDHAY215F mice produced...

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PMID: 27883180
DOI: 10.1002/eji.201646342

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BCR

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