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Article

Regulation of Reactive Oxygen Species and the Antioxidant Protein DJ-1 in Mastocytosis.

PloS one - 1 Jan 2016

Kim Do-Kyun, Beaven Michael A, Kulinski Joseph M, Desai Avanti, Bandara Geethani, Bai Yun, Prussin Calman, Schwartz Lawrence B, Komarow Hirsh, Metcalfe Dean D, Olivera Ana

Abstract excerpt

Neoplastic accumulation of mast cells in systemic mastocytosis (SM) associates with activating mutations in the receptor tyrosine kinase KIT. Constitutive activation of tyrosine kinase oncogenes has been linked to imbalances in oxidant/antioxidant mechanisms in other myeloproliferative disorders. However, the impact of KIT mutations on the redox status in SM and the potential therapeutic implications are not well...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27611333
DOI: 10.1371/journal.pone.0162831
PMCID: PMC5017616

Genes

KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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