Article
Cd19-dependent activation of Akt kinase in B-lymphocytes.
The Journal of biological chemistry - 12 Jan 2001
Otero D C, Omori S A, Rickert R C
Abstract excerpt
CD19 is rapidly phosphorylated upon B-cell antigen receptor (BCR) cross-linking, leading to the recruitment of downstream signaling intermediates. A prominent feature of CD19 signaling is the binding and activation of phosphoinositide 3-kinase (P13K), which accounts for the majority of PI3K activity induced by BCR ligation. Recent findings have implicated activation of the serine/threonine kinase Akt as imparting...
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