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Article

H2O2 production downstream of FLT3 is mediated by p22phox in the endoplasmic reticulum and is required for STAT5 signalling.

PloS one - 1 Jan 2012

Woolley John F, Naughton Ruth, Stanicka Joanna, Gough David R, Bhatt Lavinia, Dickinson Bryan C, Chang Christopher J, Cotter Thomas G

Abstract excerpt

The internal tandem duplication (ITD) of the juxtamembrane region of the FLT3 receptor has been associated with increased reactive oxygen species (ROS) generation in acute myeloid leukemia (AML). How this elevated level of ROS contributes to the leukemic phenotype, however, remains poorly understood. In this work we show that ROS in the FLT3-ITD expressing AML cell line MV4-11 is reduced by treatment with PKC412,...

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Source

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Identifiers

PMID: 22807997
DOI: 10.1371/journal.pone.0034050
PMCID: PMC3396659

Genes

FLT3

Provenance

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H2O2 production downstream of FLT3 is mediated by p22phox in the endoplasmic reticulum and is required for STAT5 signalling.PMID 22807997Read ↗

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