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Article

P66Shc mediated ferritin degradation--a novel mechanism of ROS formation.

Free radical biology & medicine - 1 Aug 2011

Borkowska Andzelika, Sielicka-Dudzin Alicja, Herman-Antosiewicz Anna, Halon Malgorzata, Wozniak Michal, Antosiewicz Jedrzej

Abstract excerpt

Diallyl trisulfide (DATS) has been shown to induce the formation of reactive oxygen species (ROS) in prostate cancer cells, which was accompanied by a decrease in the ferritin protein level and an increase in the labile iron pool (LIP). However, the mechanism of the ferritin degradation has not been fully elucidated. In this paper we demonstrate that DATS-induced ROS formation depends on p66Shc. In cells stably...

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PMID: 21616139
DOI: 10.1016/j.freeradbiomed.2011.04.045

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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