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Article

Enhanced Th17 differentiation and aggravated arthritis in IEX-1-deficient mice by mitochondrial reactive oxygen species-mediated signaling.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2012

Zhi Liang, Ustyugova Irina V, Chen Xinyuan, Zhang Qi, Wu Mei X

Abstract excerpt

CD4(+) Th1 and Th17 cells both can cause autoimmune diseases, either alone or collaboratively, if left unchecked. However, what determines the dominant Th effector phenotype in a specific autoimmune disease remains poorly understood. Our present investigation shows that null mutation of IEX-1 promotes differentiation of Th17 cells but compromises the survival of Th1 cells. The differential effect gave rise to a...

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Identifiers

PMID: 22798682
DOI: 10.4049/jimmunol.1200528
PMCID: PMC3440304

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