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Article

Targeted disruption of the inosine 5'-monophosphate dehydrogenase type I gene in mice.

Molecular and cellular biology - 1 Sept 2003

Gu Jing Jin, Tolin Amy K, Jain Jugnu, Huang Hai, Santiago Lalaine, Mitchell Beverly S

Abstract excerpt

Inosine 5'-monophosphate dehydrogenase (IMPDH) is the critical, rate-limiting enzyme in the de novo biosynthesis pathway for guanine nucleotides. Two separate isoenzymes, designated IMPDH types I and II, contribute to IMPDH activity. An additional pathway salvages guanine through the activity of hypoxanthine-guanine phosphoribosyltransferase (HPRT) to supply the cell with guanine nucleotides. In order to better...

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Identifiers

PMID: 12944494
DOI: 10.1128/MCB.23.18.6702-6712.2003
PMCID: PMC193693

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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