Article
Targeted disruption of the inosine 5'-monophosphate dehydrogenase type I gene in mice.
Molecular and cellular biology - 1 Sept 2003
Gu Jing Jin, Tolin Amy K, Jain Jugnu, Huang Hai, Santiago Lalaine, Mitchell Beverly S
Abstract excerpt
Inosine 5'-monophosphate dehydrogenase (IMPDH) is the critical, rate-limiting enzyme in the de novo biosynthesis pathway for guanine nucleotides. Two separate isoenzymes, designated IMPDH types I and II, contribute to IMPDH activity. An additional pathway salvages guanine through the activity of hypoxanthine-guanine phosphoribosyltransferase (HPRT) to supply the cell with guanine nucleotides. In order to better...
Topics
- Animals
- Cell Division
- Female
- Gene Targeting
- Genetic Engineering
- Guanine
- Guanosine Triphosphate
- Heterozygote
- Homozygote
- Hypoxanthine Phosphoribosyltransferase
- IMP Dehydrogenase
- Interleukin-4
- Isoenzymes
- Lymphocytes
- Male