Administration of an antioxidant prevents lymphoma development in transmitochondrial mice overproducing reactive oxygen species.

Abstract excerpt

Because of the difficulty to exclude possible involvement of nuclear DNA mutations, it has been a controversial issue whether pathogenic mutations in mitochondrial DNA (mtDNA) and the resultant respiration defects are involved in tumor development. To address this issue, our previous study generated transmitochondrial mice (mito-mice-ND6(13997)), which possess the nuclear and mtDNA backgrounds derived from...

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