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Article

A GPI processing phospholipase A2, PGAP6, modulates Nodal signaling in embryos by shedding CRIPTO.

The Journal of cell biology - 5 Dec 2016

Lee Gun-Hee, Fujita Morihisa, Takaoka Katsuyoshi, Murakami Yoshiko, Fujihara Yoshitaka, Kanzawa Noriyuki, Murakami Kei-Ichi, Kajikawa Eriko, Takada Yoko, Saito Kazunobu, Ikawa Masahito, Hamada Hiroshi, Maeda Yusuke, Kinoshita Taroh

Abstract excerpt

Glycosylphosphatidylinositol-anchored proteins (GPI-APs) can be shed from the cell membrane by GPI cleavage. In this study, we report a novel GPI-processing enzyme, termed post-glycosylphosphatidylinositol attachment to proteins 6 (PGAP6), which is a GPI-specific phospholipase A2 mainly localized at the cell surface. CRIPTO, a GPI-AP, which plays critical roles in early embryonic development by acting as a Nodal...

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Source

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Identifiers

PMID: 27881714
DOI: 10.1083/jcb.201605121
PMCID: PMC5147002

Genes

CRIPTO
PGAP6
GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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