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Why nature evolved GPI-anchored proteins: unique structure characteristics enable versatile cell surface functions

7 Nov 2024

Abstract excerpt

It remains a mystery why nature evolved the unique structural characteristics of GPI-anchored proteins (GPI-APs) and continues to sustain the complex, energy-intensive process of synthesizing these proteins. GPI-APs, despite their small size, rely on the coordinated activity of nearly 30 genes for their synthesis and remodeling, raising important evolutionary questions. The biological advantages of GPI-APs lie in...

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PMID: 39530348
DOI: 10.1093/glycob/cwae089

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