Survival protein anoctamin-6 controls multiple platelet responses including phospholipid scrambling, swelling, and protein cleavage.

doi:10.1096/fj.15-280446

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Article

Survival protein anoctamin-6 controls multiple platelet responses including phospholipid scrambling, swelling, and protein cleavage.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2016

Mattheij Nadine J A, Braun Attila, van Kruchten Roger, Castoldi Elisabetta, Pircher Joachim, Baaten Constance C F M J, Wülling Manuela, Kuijpers Marijke J E, Köhler Ralf, Poole Alastair W, Schreiber Rainer, Vortkamp Andrea, Collins Peter W, Nieswandt Bernhard, Kunzelmann Karl, Cosemans Judith M E M, Heemskerk Johan W M

Abstract excerpt

Scott syndrome is a rare bleeding disorder, characterized by altered Ca(2+)-dependent platelet signaling with defective phosphatidylserine (PS) exposure and microparticle formation, and is linked to mutations in the ANO6 gene, encoding anoctamin (Ano)6. We investigated how the complex platelet phenotype of this syndrome is linked to defective expression of Anos or other ion channels. Mice were generated with...

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PMID: 26481309
DOI: 10.1096/fj.15-280446

Genes

ANO6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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