Article

Glycosylphosphatidylinositol Biosynthesis and Remodeling are Required for Neural Crest Cell, Cardiac and Neural Development

2019-01-07

Abstract excerpt

The glycosylphosphatidylinositol (GPI) anchor attaches nearly 150 proteins to the cell surface. Patients with pathogenic variants in GPI biosynthetic pathway genes display an array of phenotypes including seizures, developmental delay, dysmorphic facial features and cleft palate. There is virtually no mechanism to explain these phenotypes. we identified a novel mouse mutant ( cleft lip/palate, edema and exencepha...

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Literature Corpus work: 78b64f10-74b5-58f0-97d1-7cec13530ab0
DOI: 10.1101/513507

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