Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PGAP2 is essential for correct processing and stable expression of GPI-anchored proteins.

Molecular biology of the cell - 1 Mar 2006

Tashima Yuko, Taguchi Ryo, Murata Chie, Ashida Hisashi, Kinoshita Taroh, Maeda Yusuke

Abstract excerpt

Biosynthesis of glycosylphosphatidylinositol-anchored proteins (GPI-APs) in the ER has been extensively studied, whereas the molecular events during the transport of GPI-APs from the ER to the cell surface are poorly understood. Here, we established new mutant cell lines whose surface expressions of GPI-APs were greatly decreased despite normal biosynthesis of GPI-APs in the ER. We identified a gene responsible...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD55 Antigens
Share to CD59 Antigens
Share to Cricetulus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Culture Media, Serum-Free

Share to Endoplasmic Reticulum

Share to Glycosylphosphatidylinositols

Share to Inositol

Share to Phosphates

Source

Open in PubMed Open full text

Identifiers

PMID: 16407401
DOI: 10.1091/mbc.e05-11-1005
PMCID: PMC1382328

Genes

GPI
PGAP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PGAP2 is essential for correct processing and stable expression of GPI-anchored proteins.PMID 16407401Read ↗

CHO glycosylation mutants: GPI anchor.Semantic proximity Read ↗

Hypomorphic mutations in PGAP2, encoding a GPI-anchor-remodeling protein, cause autosomal-recessive intellectual disability.Semantic proximity Read ↗

Glycosylphosphatidylinositol mannosyltransferase II is the rate-limiting enzyme in glycosylphosphatidylinositol biosynthesis under limited dolichol-phosphate mannose availability.Semantic proximity Read ↗

Identification of a Golgi GPI-N-acetylgalactosamine transferase with tandem transmembrane regions in the catalytic domain.Semantic proximity Read ↗

Active site determination of Gpi8p, a caspase-related enzyme required for glycosylphosphatidylinositol anchor addition to proteins.Semantic proximity Read ↗

Two endoplasmic reticulum (ER) membrane proteins that facilitate ER-to-Golgi transport of glycosylphosphatidylinositol-anchored proteins.Semantic proximity Read ↗

PIG-W is critical for inositol acylation but not for flipping of glycosylphosphatidylinositol-anchor.Semantic proximity Read ↗

Yeast Gaa1p is required for attachment of a completed GPI anchor onto proteins.Semantic proximity Read ↗

Comparative Haploid Genetic Screens Reveal Divergent Pathways in the Biogenesis and Trafficking of Glycophosphatidylinositol-Anchored ProteinsSemantic proximity Read ↗

Quality Control of GPI-Anchored ProteinsSemantic proximity Read ↗

Null mutation in PGAP1 impairing Gpi-anchor maturation in patients with intellectual disability and encephalopathy.Semantic proximity Read ↗

Fatty acid remodeling of GPI-anchored proteins is required for their raft association.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.