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GPI-anchored serine proteases: essential roles in development, homeostasis, and disease

1 Jan 2025

Abstract excerpt

Abstract The glycosylphosphatidylinositol (GPI)-anchored serine proteases, prostasin and testisin, have essential roles in diverse physiological functions including development, reproduction, homeostasis and barrier function of epithelia, angiogenesis, coagulation, and fibrinolysis. Important functions in pathological conditions such as cancer, kidney disease and cardiovascular disease have also been reported. In...

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PMID: 40094301
DOI: 10.1515/hsz-2024-0135

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