Article

Genetic Dissection of the role of <i>Piga</i> and <i>Pgap2</i> in the embryonic mouse brain

2025-12-11

Abstract excerpt

Glycosylphosphatidylinositol (GPI) anchors are a post-translational modification of over 150 proteins. These GPI-anchored proteins are enriched in lipid rafts in the plasma membrane and serve a variety of functions including acting as receptors and cell adhesion molecules. Human pathogenic variants in GPI biosynthesis pathway enzymes are collectively called inherited GPI deficiencies and lead to several brain anom...

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Identifiers and source

Literature Corpus work: 313dc09a-ac42-5945-9355-0ca01158a515
DOI: 10.64898/2025.12.08.692975

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