Article
Regulation of merlin by protein phosphatase 1-TIMAP and EBP50 in endothelial cells.
The international journal of biochemistry & cell biology - 1 Jan 2017
Boratkó Anita, Péter Margit, Csortos Csilla
Abstract excerpt
Merlin (moesin-ezrin-radixin like protein), the product of neurofibromatosis type 2 gene, was primarily recognized as a tumor suppressor, but it also functions as a membrane-cytoskeletal linker and regulator of multiple signaling pathways. The activity and localization of merlin is regulated by head to tail folding that is controlled by phosphorylation of the Ser518 side chain. Merlin localizes in the nucleus...
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