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Article

Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization.

The Journal of biological chemistry - 22 Mar 2002

Kissil Joseph L, Johnson Kristen C, Eckman Matthew S, Jacks Tyler

Abstract excerpt

The Nf2 tumor suppressor gene product merlin is related to the membrane-cytoskeleton linker proteins of the band 4.1 superfamily, including ezrin, radixin, and moesin (ERMs). Merlin is regulated by phosphorylation in a Rac/cdc42-dependent fashion. We report that the phosphorylation of merlin at serine 518 is induced by the p21-activated kinase PAK2. This is demonstrated by biochemical fractionation, use of active...

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Source

Identifiers

PMID: 11782491
DOI: 10.1074/jbc.M200083200

Genes

PAK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization.PMID 11782491Read ↗

p21-activated Kinase Links Rac/Cdc42 Signaling to MerlinSemantic proximity Read ↗

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Effect of merlin phosphorylation on neurofibromatosis 2 (NF2) gene function.Semantic proximity Read ↗

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Tumor-suppression functions of merlin are independent of its role as an organizer of the actin cytoskeleton in Schwann cellsSemantic proximity Read ↗

Distinct overlapping sequences at the carboxy-terminus of merlin regulate its tumour suppressor and morphogenic activity.Semantic proximity Read ↗

Merlin, a "magic" linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survival.Semantic proximity Read ↗

Structural Analysis of Drosophila Merlin Reveals Functional Domains Important for Growth Control and Subcellular LocalizationSemantic proximity Read ↗

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