Article
Shedding light on Merlin's wizardry.
Trends in cell biology - 1 May 2007
Okada Tomoyo, You Liru, Giancotti Filippo G
Abstract excerpt
Inactivation of the tumor suppressor Merlin, encoded by the NF2 (Neurofibromatosis type 2) gene, contributes to malignant conversion in many cell types. Merlin is an Ezrin-Radixin-Moesin protein and localizes underneath the plasma membrane at cell-cell junctions and other actin-rich sites. Recent studies indicate that Merlin mediates contact inhibition of proliferation by blocking recruitment of Rac to the plasma...
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