Article
Protein kinase C regulates the phosphorylation and oligomerization of ERM binding phosphoprotein 50.
Experimental cell research - 15 May 2005
Fouassier Laura, Nichols Matthew T, Gidey Elizabeth, McWilliams Ryan R, Robin Hélène, Finnigan Claire, Howell Kathryn E, Housset Chantal, Doctor R Brian
Abstract excerpt
Ezrin-Radixin-Moesin (ERM) binding phosphoprotein 50 (EBP50, a.k.a. NHERF-1) is a scaffold protein essential for the localization and coordinated activity of apical transporters, enzymes and receptors in epithelial cells. EBP50 acts via multiple protein binding interactions, including oligomerization through interactions of its PSD95-Dlg-ZO1 (PDZ) domains. EBP50 can be phosphorylated on multiple sites and...
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