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Article

Distinct overlapping sequences at the carboxy-terminus of merlin regulate its tumour suppressor and morphogenic activity.

Journal of cellular and molecular medicine - 1 Sept 2012

Laulajainen Minja, Melikova Maria, Muranen Taru, Carpén Olli, Grönholm Mikaela

Abstract excerpt

The Neurofibromatosis 2 (NF2) gene product merlin is a tumour suppressor, which in addition to inhibiting cell proliferation regulates cell morphology. The morphogenic properties of merlin may play a role in tumour suppression, as patient-derived tumour cells demonstrate cytoskeletal abnormalities. However, it is still unclear how these functions are linked. The N-terminal FERM-domain of merlin is highly...

Topics

Amino Acid Sequence
Animals
COS Cells
Cell Proliferation
Chlorocebus aethiops
Cytoskeletal Proteins
Cytoskeleton
Fluorescent Antibody Technique
Gene Expression Regulation
Genes, Tumor Suppressor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HEK293 Cells

Humans

Immunoblotting

Mice

Molecular Sequence Data

Neurofibromin 2

Phenotype

Phosphorylation

Source

Open in PubMed Open full text

Identifiers

PMID: 22325036
DOI: 10.1111/j.1582-4934.2012.01525.x
PMCID: PMC3822986

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Distinct overlapping sequences at the carboxy-terminus of merlin regulate its tumour suppressor and morphogenic activity.PMID 22325036Read ↗

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