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Article

Merlin, a tumor suppressor, interacts with transactivation-responsive RNA-binding protein and inhibits its oncogenic activity.

The Journal of biological chemistry - 16 Jul 2004

Lee Joo Yong, Kim Hongtae, Ryu Chung Hun, Kim Jae Young, Choi Byung Hyune, Lim Young, Huh Pil-Woo, Kim Young-Hoon, Lee Kweon-Haeng, Jun Tae-Youn, Rha Hyung Kyun, Kang Joon-Ki, Choi Chang Rak

Abstract excerpt

The neurofibromatosis type 2 gene-encoded protein, merlin, is related to the ERM (ezrin, radixin, and moesin) family of membrane-cytoskeleton-associated proteins. Recent studies suggest that the loss of neurofibromatosis type 2 function contributes to tumor development and metastasis. Although the cellular functions of merlin as a tumor suppressor are relatively well characterized, the cellular mechanism whereby...

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PMID: 15123692
DOI: 10.1074/jbc.M312083200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Merlin, a tumor suppressor, interacts with transactivation-responsive RNA-binding protein and inhibits its oncogenic activity.PMID 15123692Read ↗

Merlin, a "magic" linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survival.Semantic proximity Read ↗

Homotypic and heterotypic interaction of the neurofibromatosis 2 tumor suppressor protein merlin and the ERM protein ezrinSemantic proximity Read ↗

Shedding light on Merlin's wizardry.Semantic proximity Read ↗

Interaction between two isoforms of the NF2 tumor suppressor protein, merlin, and between merlin and ezrin, suggests modulation of ERM proteins by merlinSemantic proximity Read ↗

Tumor-suppression functions of merlin are independent of its role as an organizer of the actin cytoskeleton in Schwann cellsSemantic proximity Read ↗

The tumor suppressor merlin interacts with microtubules and modulates Schwann cell microtubule cytoskeletonSemantic proximity Read ↗

Structural Analysis of Drosophila Merlin Reveals Functional Domains Important for Growth Control and Subcellular LocalizationSemantic proximity Read ↗

Merlin/Neurofibromatosis Type 2 Suppresses Growth by Inhibiting the Activation of Ras and RacSemantic proximity Read ↗

Merlin is a potent inhibitor of glioma growth.Semantic proximity Read ↗

Detection of cellular proteins that interact with the NF2 tumor suppressor gene product.Semantic proximity Read ↗

Merlin differentially associates with the microtubule and actin cytoskeletonSemantic proximity Read ↗

Distinct overlapping sequences at the carboxy-terminus of merlin regulate its tumour suppressor and morphogenic activity.Semantic proximity Read ↗

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