Article
Akt phosphorylation regulates the tumour-suppressor merlin through ubiquitination and degradation.
Nature cell biology - 1 Oct 2007
Tang Xiaoling, Jang Sung-Wuk, Wang Xuerong, Liu Zhixue, Bahr Scott M, Sun Shi-Yong, Brat Daniel, Gutmann David H, Ye Keqiang
Abstract excerpt
The neurofibromatosis-2 (NF2) tumour-suppressor gene encodes an intracellular membrane-associated protein, called merlin, whose growth-suppressive function is dependent on its ability to form interactions through its intramolecular amino-terminal domain (NTD) and carboxy-terminal domain (CTD). Merlin phosphorylation plays a critical part in dictating merlin NTD/CTD interactions as well as in controlling binding...
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