Article
Detection of mutations in the BRAF gene in patients with KIT and PDGFRA wild-type gastrointestinal stromal tumors.
Virchows Archiv : an international journal of pathology - 1 Jan 2017
Jasek Karin, Buzalkova Veronika, Minarik Gabriel, Stanclova Andrea, Szepe Peter, Plank Lukas, Lasabova Zora
Abstract excerpt
Gastrointestinal stromal tumors (GISTs) are characterized by mutations in exons 9, 11, 13, and 17 of KIT or exons 12, 14, and 18 of PDGFRA gene. However, approximately 10 to 15 % of GISTs lack the mutations in KIT and PDGFRA, and these are referred to as wild-type GISTs which are less sensitive to tyrosine-kinase inhibitors. The aim of this study was to detect BRAF mutations in patients with wild-type GISTs. We...
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