Article
KIT and PDGFRA mutations in gastrointestinal stromal tumors (GISTs).
Seminars in diagnostic pathology - 1 May 2006
Lasota Jerzy, Miettinen Markku
Abstract excerpt
Mutually exclusive KIT and PDGFRA mutations are central events in GIST pathogenesis, and their understanding is becoming increasingly important, because specific treatment targeting oncogenic KIT and PDGFRA activation (especially imatinib mesylate) has become available. KIT mutations in GIST are clustered in four exons. Most common are exon 11 (juxtamembrane domain) mutations that include deletions, point...
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