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Article

Spectrum of mutations in gastrointestinal stromal tumor patients - a population-based study from Slovakia.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 Jun 2013

Minárik Gabriel, Plank Lukáš, Lasabová Zora, Szemes Tomáš, Burjanivová Tatiana, Szépe Peter, Buzalková Veronika, Porubský David, Sufliarsky Jozef

Abstract excerpt

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of gastrointestinal tract and are characterized by presence of mutations in tyrosine kinases cKIT (KIT) and PDGFRα (PDGFRA). Mutations identified are highly heterogeneous, but some mutations are associated with specific clinical features of the tumor. Samples from 278 GIST patients collected during the period 2004-2011 were screened...

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Source

Identifiers

PMID: 23106360
DOI: 10.1111/apm.12019

Genes

KIT
PDGFRA

Variants

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Source receipt: pubmed, retrieved 7 Sept 2026.

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