Article
Intratumoral KIT mutational heterogeneity and recurrent KIT/ PDGFRA mutations in KIT/PDGFRA wild-type gastrointestinal stromal tumors.
Oncotarget - 24 May 2016
Gao Jing, Li Jian, Li Yanyan, Li Zhongwu, Gong Jifang, Wu Jian, Liu Na, Dong Bin, Qi Changsong, Li Jie, Shen Lin
Abstract excerpt
OBJECTIVE: Gastrointestinal stromal tumors (GISTs) with no mutations in exons 9, 11, 13, and 17 of the KIT gene and exons 12, and 18 of the PDGFRA gene were defined as KIT/PDGFRA wild-type and they accounted for ~15-20% of GISTs. However, some KIT/PDGFRA wild-type GISTs with KIT mutations in other exons were occasionally reported. We therefore assessed GISTs to understand the whole genomic genotypes of KIT or...
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