Article
V600E BRAF mutations are alternative early molecular events in a subset of KIT/PDGFRA wild-type gastrointestinal stromal tumours.
Journal of clinical pathology - 1 Jul 2009
Agaimy A, Terracciano L M, Dirnhofer S, Tornillo L, Foerster A, Hartmann A, Bihl M P
Abstract excerpt
BACKGROUND: A small subset (10-15%) of gastrointestinal stromal tumours (GISTs) lack mutations in KIT and PDGFRA (wild-type GIST). Recently, a novel BRAF exon 15 mutation (V600E) was detected in imatinib-naive wild-type high-risk intestinal GISTs (4%). However, the frequency and distribution of BRAF mutations within the spectrum of GISTs, and whether they might represent secondary events acquired during tumour...
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