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Article

Somatic mutational spectrum analysis in a prospective series of 104 gastrointestinal stromal tumors.

Oncology reports - 1 Mar 2017

Guenat David, Deroo Olivier, Magnin Sandrine, Chaigneau Loïc, Monnien Franck, Borg Christophe, Mougin Christiane, Emile Jean-François, Prétet Jean-Luc

Abstract excerpt

Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors distinguished by driver mutations in proto-oncogenes KIT or PDGFRA in 85-90% of cases. These mutations have been linked to the response to imatinib, a multikinase inhibitor, and have independent prognostic impact. Here, we describe the prospective study of the molecular characteristics of 104 GISTs from French adult patients analyzed routinely through...

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Source

Identifiers

PMID: 28098915
DOI: 10.3892/or.2017.5384

Genes

KIT
PDGFRA
BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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