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Article

Somatic mutational spectrum analysis in a prospective series of 104 gastrointestinal stromal tumors.

Oncology reports - 1 Mar 2017

Guenat David, Deroo Olivier, Magnin Sandrine, Chaigneau Loïc, Monnien Franck, Borg Christophe, Mougin Christiane, Emile Jean-François, Prétet Jean-Luc

Abstract excerpt

Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors distinguished by driver mutations in proto-oncogenes KIT or PDGFRA in 85-90% of cases. These mutations have been linked to the response to imatinib, a multikinase inhibitor, and have independent prognostic impact. Here, we describe the prospective study of the molecular characteristics of 104 GISTs from French adult patients analyzed routinely through...

Topics

Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
Exons
Female
Gastrointestinal Neoplasms
Gastrointestinal Stromal Tumors
Humans
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Neoplasm Staging

Polymerase Chain Reaction

Prognosis

Prospective Studies

Proto-Oncogene Proteins c-kit

Proto-Oncogene Proteins p21(ras)

Source

Identifiers

PMID: 28098915
DOI: 10.3892/or.2017.5384

Genes

KIT
PDGFRA
BRAF
KRAS

Provenance

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