Article
Clinicopathological and molecular features of a large cohort of gastrointestinal stromal tumors (GISTs) and review of the literature: BRAF mutations in KIT/PDGFRA wild-type GISTs are rare events.
Human pathology - 1 Apr 2017
Huss Sebastian, Pasternack Helen, Ihle Michaela Angelika, Merkelbach-Bruse Sabine, Heitkötter Birthe, Hartmann Wolfgang, Trautmann Marcel, Gevensleben Heidrun, Büttner Reinhard, Schildhaus Hans-Ulrich, Wardelmann Eva
Abstract excerpt
In KIT/PDGFRA wild-type gastrointestinal stromal tumors (wt-GISTs), BRAF mutations are regarded as alternative pathogenic events driving tumorigenesis. In our study, we aimed at analyzing a large cohort (n=444) of GISTs for BRAF mutations using molecular and immunohistochemical methods. More than 3000 GIST samples from caucasian patients were available in our GIST and Sarcoma Registry NRW. Of these, we selected...
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