Article
Human MHC Class II and Invariant Chain Knock-in Mice Mimic Rheumatoid Arthritis with Allele Restriction in Immune Response and Arthritis Association.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Jun 2024
Romero-Castillo Laura, Li Taotao, Do Nhu-Nguyen, Sareila Outi, Xu Bingze, Hennings Viktoria, Xu Zhongwei, Svensson Carolin, Oliveira-Coelho Ana, Sener Zeynep, Urbonaviciute Vilma, Ekwall Olov, Burkhardt Harald, Holmdahl Rikard
Abstract excerpt
Transgenic mice expressing human major histocompatibility complex class II (MHCII) risk alleles are widely used in autoimmune disease research, but limitations arise due to non-physiologic expression. To address this, physiologically relevant mouse models are established via knock-in technology to explore the role of MHCII in diseases like rheumatoid arthritis. The gene sequences encoding the ectodomains are...
Topics
- Animals
- Mice
- Arthritis, Rheumatoid
- Antigens, Differentiation, B-Lymphocyte
- Humans
- Disease Models, Animal
- Mice, Inbred C57BL
- Mice, Transgenic
- Gene Knock-In Techniques