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Article

SP110b Controls Host Immunity and Susceptibility to Tuberculosis.

American journal of respiratory and critical care medicine - 1 Feb 2017

Leu Jia-Shiun, Chen Mei-Ling, Chang So-Yi, Yu Sung-Liang, Lin Chia-Wei, Wang Hsuan, Chen Wan-Chen, Chang Chin-Hao, Wang Jann-Yuan, Lee Li-Na, Yu Chong-Jen, Kramnik Igor, Yan Bo-Shiun

Abstract excerpt

RATIONALE: How host genetic factors affect Mycobacterium tuberculosis (Mtb) infection outcomes remains largely unknown. SP110b, an IFN-induced nuclear protein, is the nearest human homologue to the mouse Ipr1 protein that has been shown to control host innate immunity to Mtb infection. However, the function(s) of SP110b remains unclear. OBJECTIVES: To elucidate the role of SP110b in controlling host immunity and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27858493
DOI: 10.1164/rccm.201601-0103OC
PMCID: PMC5328177

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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