Article
Polymorphisms of SP110 are associated with both pulmonary and extra-pulmonary tuberculosis among the Vietnamese.
PloS one - 1 Jan 2014
Fox Gregory J, Sy Dinh Ngoc, Nhung Nguyen Viet, Yu Bing, Ellis Magda K, Van Hung Nguyen, Cuong Nguyen Kim, Thi Lien Luu, Marks Guy B, Saunders Bernadette M, Britton Warwick J
Abstract excerpt
BACKGROUND: Tuberculosis (TB) is an infectious disease that remains a major cause of morbidity and mortality worldwide, yet the reasons why only 10% of people infected with Mycobacterium tuberculosis go on to develop clinical disease are poorly understood. Genetically determined variation in the host immune response is one factor influencing the response to M. tuberculosis. SP110 is an interferon-responsive...
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