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Article

Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons.

eLife - 21 Jun 2021

Ji Daisy X, Witt Kristen C, Kotov Dmitri I, Margolis Shally R, Louie Alexander, Chevée Victoria, Chen Katherine J, Gaidt Moritz M, Dhaliwal Harmandeep S, Lee Angus Y, Nishimura Stephen L, Zamboni Dario S, Kramnik Igor, Portnoy Daniel A, Darwin K Heran, Vance Russell E

Abstract excerpt

Type I interferons (IFNs) are essential for anti-viral immunity, but often impair protective immune responses during bacterial infections. An important question is how type I IFNs are strongly induced during viral infections, and yet are appropriately restrained during bacterial infections. The Super susceptibility to tuberculosis 1 (Sst1) locus in mice confers resistance to diverse bacterial infections. Here we...

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Identifiers

PMID: 34151776
DOI: 10.7554/eLife.67290
PMCID: PMC8248984

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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