Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Variants in the SP110 gene are associated with genetic susceptibility to tuberculosis in West Africa.

Proceedings of the National Academy of Sciences of the United States of America - 5 Jul 2006

Tosh Kerrie, Campbell Sarah J, Fielding Katherine, Sillah Jackson, Bah Boubacar, Gustafson Per, Manneh Kebba, Lisse Ida, Sirugo Giorgio, Bennett Steve, Aaby Peter, McAdam Keith P W J, Bah-Sow Oumou, Lienhardt Christian, Kramnik Igor, Hill Adrian V S

Abstract excerpt

The sst1 locus has been identified in a mouse model to control resistance and susceptibility of Mycobacterium tuberculosis infection. Subsequent studies have now identified Ipr1 (intracellular pathogen resistance 1) to be the gene responsible. Ipr1 is encoded within the sst1 locus and is expressed in the tuberculosis lung lesions and macrophages of sst1-resistant, but not sst1-susceptible mice. We have therefore...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Africa
Share to Disease Transmission, Infectious

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Haplotypes

Share to Minor Histocompatibility Antigens

Share to Mycobacterium tuberculosis

Share to Nuclear Proteins

Share to Tuberculosis

Source

Open in PubMed Open full text

Identifiers

PMID: 16803959
DOI: 10.1073/pnas.0603340103
PMCID: PMC1502463

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variants in the SP110 gene are associated with genetic susceptibility to tuberculosis in West Africa.PMID 16803959Read ↗

Association of SP110 gene polymorphisms with susceptibility to tuberculosis in a Chinese population.Semantic proximity Read ↗

Resequencing and association analysis of the SP110 gene in adult pulmonary tuberculosis.Semantic proximity Read ↗

No associations of human pulmonary tuberculosis with Sp110 variantsSemantic proximity Read ↗

SP110 polymorphisms are not associated with pulmonary tuberculosis in a South African population.Semantic proximity Read ↗

Polymorphisms in SP110 are not associated with pulmonary tuberculosis in Indonesians.Semantic proximity Read ↗

SP110b Controls Host Immunity and Susceptibility to Tuberculosis.Semantic proximity Read ↗

Genetic dissection of host resistance to Mycobacterium tuberculosis: the sst1 locus and the Ipr1 gene.Semantic proximity Read ↗

SP110 gene polymorphisms and tuberculosis susceptibility: a systematic review and meta-analysis based on 10 624 subjects.Semantic proximity Read ↗

Polymorphisms of SP110 are associated with both pulmonary and extra-pulmonary tuberculosis among the Vietnamese.Semantic proximity Read ↗

SP110 and PMP22 polymorphisms are associated with tuberculosis risk in a Chinese-Tibetan population.Semantic proximity Read ↗

SP110 as a novel susceptibility gene for Mycobacterium avium subspecies paratuberculosis infection in cattle.Semantic proximity Read ↗

Genetic association study suggests a role for SP110 variants in lymph node tuberculosis but not pulmonary tuberculosis in north Indians.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.