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Transcriptional regulators SP110 and SP140 modulate inflammatory response genes in Mycobacterium tuberculosis -infected human macrophages

20 Aug 2024

Abstract excerpt

ABSTRACT Understanding the functions of human transcriptional regulatory genes SP110 and SP140 during Mycobacterium tuberculosis infection is crucial; in a mouse model, homologous genes Sp110 and Sp140 have been shown to negatively regulate inflammatory response genes, including the type I interferon (IFN) response. The reduction of these genes in mice is associated with susceptibility to M. tuberculosis...

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PMID: 39162523
DOI: 10.1128/spectrum.00101-24

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