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Article

E-cadherin genetic variants predict survival outcome in breast cancer patients.

Journal of translational medicine - 16 Nov 2016

Memni Hager, Macherki Yosra, Klayech Zahra, Ben-Haj-Ayed Ahlem, Farhat Karim, Remadi Yassmine, Gabbouj Sallouha, Mahfoudh Wijden, Bouzid Nadia, Bouaouina Noureddine, Chouchane Lotfi, Zakhama Abdelfattah, Hassen Elham

Abstract excerpt

BACKGROUND: E-cadherin is a major component of adherens junctions that regulates cell shape and maintains tissue integrity. A complete loss or any decrease in cell surface expression of E-cadherin will interfere with the cell-to-cell junctions' strength and leads to cell detachment and escape from the primary tumor site. In this prospective study, three functional single nucleotide polymorphisms (-347G/GA,...

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Identifiers

PMID: 27852262
DOI: 10.1186/s12967-016-1077-4
PMCID: PMC5112645

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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