Article
Breast cancer susceptibility risk associations and heterogeneity by E-cadherin tumor tissue expression.
Breast cancer research and treatment - 1 Jan 2014
Horne Hisani N, Sherman Mark E, Garcia-Closas Montserrat, Pharoah Paul D, Blows Fiona M, Yang Xiaohong R, Hewitt Stephen M, Conway Catherine M, Lissowska Jolanta, Brinton Louise A, Prokunina-Olsson Ludmila, Dawson Sarah-Jane, Caldas Carlos, Easton Douglas F, Chanock Stephen J, Figueroa Jonine D
Abstract excerpt
E-cadherin is involved in cell-cell adhesion and epithelial-to-mesenchymal transitions. In cancers, loss or inactivation of E-cadherin is associated with epithelial cell proliferation and invasion. Here, we sought to determine, if risk associations for 18 breast cancer susceptibility single nucleotide polymorphisms (SNPs) differed by E-cadherin tumor tissue expression in the Polish Breast Cancer Study (PBCS),...
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