Article
A common and functional gene variant in the vascular endothelial growth factor a predicts clinical outcome in early-stage breast cancer.
Molecular carcinogenesis - 1 Nov 2013
Absenger Gudrun, Szkandera Joanna, Stotz Michael, Pichler Martin, Winder Thomas, Langsenlehner Tanja, Langsenlehner Uwe, Samonigg Hellmut, Renner Wilfried, Gerger Armin
Abstract excerpt
Angiogenesis and cell cycle control play critical roles in breast cancer susceptibility and clinical outcome and are mainly controlled by vascular endothelial growth factor (VEGF) and cyclin-dependent kinases, respectively. Functional germline polymorphisms in these genes alter the function, ther...
Topics
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
- Breast Neoplasms
- Cyclin D1
- Female
- Follow-Up Studies
- Genotype
- Humans
- Male
- Middle Aged