Article
E-cadherin gene mutations are rare in adenocarcinomas of the oesophagus.
British journal of cancer - 1 Jul 1999
Wijnhoven B P, de Both N J, van Dekken H, Tilanus H W, Dinjens W N
Abstract excerpt
Reduced expression of E-cadherin, a cell-cell adhesion molecule, is observed in oesophageal adenocarcinomas and correlates with less favourable pathological parameters and survival. To determine if genetic events lead to reduced E-cadherin expression in these patients, we screened all 16 exons of the E-cadherin gene for mutations with the polymerase chain reaction single-strand conformation polymorphism analysis...
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